Invited Review
Animal models of tauopathies and their implications for
research/translation into the clinic
Simon Dujardin, Morvane Colin* and Luc Buée DOI: 10.1111/nan.12200
Author Information
Inserm, UMR1172 Jean-Pierre Aubert research centre, Lille, France ;
Université de Lille, Faculté de Médecine, Lille, France; CHRU, Memory Clinic,
Lille, France
* Corresponding authors: Drs L. Buée & M. Colin Inserm UMR1172,
‘Alzheimer & Tauopathies’ Bâtiment Biserte, rue Polonovski 59045 Lille
Cedex, France Tel: +33 320 298850, Fax: +33 220 538562 Emails:
morvane.colin@inserm.fr, luc.buee@inserm.fr
This article has been accepted for publication and undergone full peer
review but has not been through the copyediting, typesetting, pagination and
proofreading process, which may lead to differences between this version and the
Version of Record. Please cite this article as doi: 10.1111/nan.12200
Publication History Accepted manuscript online: 26 NOV 2014 10:37PM EST
Manuscript Accepted: 23 NOV 2014
Keywords:
Alzheimer's disease; prion; propagation; tau protein; phosphorylation;
aggregation; neurodegeneration; therapeutic approaches
Abstract
Our aims are to review animal models of tauopathies, which include a number
of brain disorders with various aetiologies, including aging, genetics,
infectious diseases, toxins, trauma, and other unknown factors. Tauopathies are
characterised by the accumulation of filaments of the microtubule-associated tau
protein. The different aetiopathogeneses and distinct molecular events involved
in tau aggregation have led to the development of various animal models for
these diseases.
In this review, rather than listing all current models, we focus on
specific animal models addressing, among others, the question of tau
hyperphosphorylation, tau aggregation and tau spreading. Physiological
conditions, including normal aging and hibernation, may exhibit tau
phosphorylation and some aspects of tauopathies. However, most of the models of
tauopathies involve genetically modified animals (mostly rodents, but also fruit
fly, zebrafish, and worm). Some of these models have been crucial for the
development of therapeutic approaches in humans.
The present review shows the difficulty in pinpointing a specific mechanism
that may be targeted in tauopathies but also opens up new avenues for innovative
therapeutic strategies.
Monday, November 17, 2014
Prion-like transmission and spreading of tau pathology
Wednesday, June 19, 2013
Spreading of tau pathology in Alzheimer's disease by cell-to-cell
transmission
Saturday, May 25, 2013
Brain homogenates from human tauopathies induce tau inclusions in mouse
brain
Sunday, November 23, 2014
Transmission Characteristics of Variably Protease-Sensitive Prionopathy
* We concluded that VPSPr is transmissible; thus, it is an authentic prion
disease.
Self-Propagative Replication of Ab Oligomers Suggests Potential
Transmissibility in Alzheimer Disease
Received July 24, 2014; Accepted September 16, 2014; Published November 3,
2014
Singeltary comment ;
Monday, November 3, 2014
USA CJD TSE PRION UNIT, TEXAS, SURVEILLANCE UPDATE NOVEMBER 2014
National Prion Disease Pathology Surveillance Center Cases Examined1
(October 7, 2014)
***6 Includes 11 cases in which the diagnosis is pending, and 19
inconclusive cases;
***7 Includes 12 (11 from 2014) cases with type determination pending in
which the diagnosis of vCJD has been excluded.
***The sporadic cases include 2660 cases of sporadic Creutzfeldt-Jakob
disease (sCJD),
***50 cases of Variably Protease-Sensitive Prionopathy (VPSPr)
***and 21 cases of sporadic Fatal Insomnia (sFI).
Sunday, November 23, 2014
Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas in
June 2014 confirmed as USA case NOT European
TSS
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